Associate Director / Senior Scientist II, Structural Biology

REVOLUTION Medicines discovers and develops new drugs that translate frontier cancer targets through exceptional drug discovery delivering revolutionary medicines on behalf of cancer patients. Our innovative science draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches. As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.


As a key scientific leader within our Discovery Technologies department you will:

  • Lead our Structural Biology team to enable structure-based drug design through optimization of crystallization constructs and conditions, and solution of X-ray structures.

  • Leverage leading technologies to optimize crystallization throughput, including fragment crystal screens.

  • Design novel constructs (e.g. mutants, truncations) and access alternative measurement modalities (e.g. NMR, RT crystallography) to support structure/function exploration of protein targets.

  • Collaborate with multi-disciplinary project teams to enable structure guided drug design.

  • Be part of our New Projects team, providing expert structural analysis and ligandability assessments for frontier cancer targets.

  • Identify and manage CROs to obtain diffraction data and ensure sufficient access to crystal structures.

  • Interface with computational chemists and biologists to generate novel insights that fuel drug development.

Required Skills
  • Ph.D. degree in Structural Biology, Biophysics, or related field.

  • 8+ years of small molecule drug discovery experience with a strong track record of scientific leadership and innovation.

  • Expertise in protein and protein-ligand complex crystallization, x-ray data collection and refinement.

  • Experience in imaging technologies and preparation of protein ligand complexes and their characterizations.

  • Understanding of structure-based drug discovery to advance therapeutic programs with a proven track record of collaboration with medicinal and computational chemists.

  • Excellent written and verbal communication skills to work with interdepartmental teams.

  • Innovative, team-player with high energy for our small company environment.

  • Demonstrated ability to lead, plan and achieve research goals as part of an interdisciplinary team.