Senior Scientist, Medicinal Chemistry

REVOLUTION Medicines discovers and develops new drugs that translate frontier cancer targets through exceptional drug discovery delivering revolutionary medicines on behalf of cancer patients. Our innovative science draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches. As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.


As a key member of the Chemistry team, you will:

  • Have a fresh, dynamic and “can-do” attitude.  You will be a role model for leading from the bench with respect to high quality compound design through to synthesis execution.

  • Analyze project data and communicate findings and recommendations to a variety of stakeholders.

  • Partner in the scientific activities of other outstanding medicinal chemists in the department and help create an environment where we channel scientific curiosity to build and deliver a sustainable portfolio.

  • Drive the design and multi-parameter optimization of novel hits and lead series for frontier cancer targets; provide project updates and strategic vision for med chem activities as appropriate.

  • Represent REVOLUTION Medicines with external organizations and help build the scientific reputation for our novel Drug Discovery paradigm through a variety of external disclosures.

  • Enhance our operational efficiency & flexibility through continuous improvement activities and implementation of best practice.

  • Embrace all sources of innovation to improve project success rates and expand our target space.

  • Secure our junior chemists future scientific & career growth through high quality coaching and mentoring.

  • Demonstrate commitment to the RevMed chemistry department vision to ensure we are acknowledged both internally and externally as a world-class chemistry team focussed on frontier cancer targets.

  • Advance the RevMed Research Portfolio and company value through presentation/publication of project results in scientific meetings and peer-reviewed literature as guided by RevMed publication policies to build our scientific reputation.

  • Be instrumental in the successfully delivery of a range of anti-cancer Drug Candidates for frontier oncology targets.

Required Skills
  • Ph.D. degree in chemistry with a deep understanding of medicinal and synthetic chemistry, from hit generation through to candidate selection.

  • Ideally over 5+ years of drug discovery experience in the pharmaceutical/biotech industry with a strong track record of scientific leadership, innovation, generation of high quality, tractable lead series and candidate drug delivery.

  • Excellent written and verbal communication skills to work with interdepartmental teams.

  • Innovative team-player with high energy for our start-up environment.

  • Demonstrated ability to lead, plan and achieve research goals as part of an interdisciplinary team.

  • Excellent written and verbal communication skills.

  • Significant experience with structure-based drug discovery is highly desirable.